Dosis sola facit venenum (Paracelsus 1493–1541)

Toxicology is an applied science, dealing with potential effects of chemicals at large on living organisms. It uses concepts and findings of many different scientific areas such as biology, chemistry, pharmacology and medicine. Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541), also called Paracelsus and considered the father of toxicology¹, said: ‘All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous’ (abbreviated translation shown above: ‘Dosis sola facit venenum’).

This website serves mainly for the publication of some documents related to preclinical safety (PCS) assessment as used by Ettlin Consulting. Internal links connect to those parts of the website, where the topic is addressed in some detail, and can be accessed by clicking on words in green (examples see the list below).

Ettlin Consulting documents are accessible by clicking on words in red preceded by the symbol  . These documents belong to the following categories:

There are also links to some external websites, which can be accessed by clicking on words in blue preceded by the symbol  . These external websites were accessible in January 2021.

The links are examples of toxicological issues, take up some keywords and generally focus on preclinical toxicity aspects of drugs. The area of drug metabolism and pharmacokinetics including absorption, distribution and excretion (ADME) is only partly mentioned, e.g. in Summaries of regulatory development related to PCS and in particular in the overview on ADME-related studies.

The website offers only a glimpse at PCS and does not replace e.g. textbooks on toxicology.


¹ The portrait of Theophrastus Phillipus Auroleus Bombastus von Hohenheim (Paracelsus) is shown above